Studies of the pattern recognition molecule H-ficolin: specificity and purification.

@article{Zacho2012StudiesOT,
  title={Studies of the pattern recognition molecule H-ficolin: specificity and purification.},
  author={Rikke M Zacho and Lisbeth Jensen and Randi Terp and Jens Christian Jensenius and Steffen Thiel},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 11},
  pages={8071-81}
}
Ficolins are pattern recognition molecules of the innate immune system. H-ficolin is found in plasma associated with mannan-binding lectin-associated serine proteases (MASPs). When H-ficolin binds to microorganisms the MASPs are activated, which in turn activate the complement system. H-ficolin is the most abundant ficolin in humans, yet its ligand binding characteristics and biological role remain obscure. We examined the binding of H-ficolin to Aerococcus viridans as well as to a more defined… CONTINUE READING