Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.

@article{Holmes1967StudiesOT,
  title={Studies of the metabolic activity of leukocytes from patients with a genetic abnormality of phagocytic function.},
  author={Beulah Holmes and Andrea Page and Robert Alan Good},
  journal={The Journal of clinical investigation},
  year={1967},
  volume={46 9},
  pages={1422-32}
}
Polymorphonuclear leukocytes from patients with chronic granulomatous disease respond to the phagocytosis of latex particles with normal increments in glucose consumption, lactate production, Krebs' cycle activity, and lipid turnover. The leukocytes of these patients fail to show normal increments in respiration, direct oxidation of glucose, and hydrogen peroxide formation during particle uptake. It appears that the stimulation of respiration with the formation of hydrogen peroxide and… CONTINUE READING
87 Citations
1 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 87 extracted citations

References

Publications referenced by this paper.

Metabolic basis of phagocytic activity

  • D. Rowley
  • Physiol . Rev .
  • 1962

Similar Papers

Loading similar papers…