Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin.

@article{Steinhauer1995StudiesOT,
  title={Studies of the membrane fusion activities of fusion peptide mutants of influenza virus hemagglutinin.},
  author={David A. Steinhauer and Steve A. Wharton and John J. Skehel and Don C. Wiley},
  journal={Journal of virology},
  year={1995},
  volume={69 11},
  pages={6643-51}
}
Influenza virus hemagglutinin (HA) fuses membranes at endosomal pH by a process which involves extrusion of the NH2-terminal region of HA2, the fusion peptide, from its buried location in the native trimer. We have examined the amino acid sequence requirements for a functional fusion peptide by determining the fusion capacities of site-specific mutant HAs expressed by using vaccinia virus recombinants and of synthetic peptide analogs of the mutant fusion peptides. The results indicate that for… CONTINUE READING

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