Studies of the enzymic mechanism of the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) by rat liver microsomes.

@article{Neal1967StudiesOT,
  title={Studies of the enzymic mechanism of the metabolism of diethyl 4-nitrophenyl phosphorothionate (parathion) by rat liver microsomes.},
  author={R. A. Neal},
  journal={The Biochemical journal},
  year={1967},
  volume={105 1},
  pages={
          289-97
        }
}
  • R. A. Neal
  • Published 1967
  • Chemistry, Medicine
  • The Biochemical journal
1. The metabolism of parathion by rat liver microsomes is affected by various enzyme inhibitors in a manner quite typical of the ;mixed-function oxidase' enzyme systems. 2. With many of these inhibitors (p-chloromercuribenzoate, Cu(2+), 8-hydroxyquinoline) the conversion of parathion into diethyl hydrogen phosphorothionate is less inhibited than conversion into diethyl 4-nitrophenyl phosphate (paraoxon). 3. Compounds containing reduced sulphur stimulate the overall metabolism of parathion… Expand
The role of liver microsomal enzymes in the metabolism of parathion.
A comparison of the in vitro metabolism of parathion in the lung and liver of the rabbit.
  • R. A. Neal
  • Chemistry, Medicine
  • Toxicology and applied pharmacology
  • 1972
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