Studies of the efficacy and potential hazards of methylene blue therapy in aniline‐induced methaemoglobinaemia

@article{Harvey1983StudiesOT,
  title={Studies of the efficacy and potential hazards of methylene blue therapy in aniline‐induced methaemoglobinaemia},
  author={John W Harvey and A S Keitt},
  journal={British Journal of Haematology},
  year={1983},
  volume={54}
}
Summary. The similarity between poison and antidote was known to the ancient Greeks who used the same word, pharmakon, for both. This paper presents evidence that aniline (the toxin) and methylene blue (the therapy) are in fact remarkably similar and additive in some of their effects on erythrocytes. Studies were prompted by a case of aniline‐induced methaemoglobinaemia in which two injections of methylene blue did not rapidly eliminate cyanosis and were followed by severe, delayed haemolysis… 
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TLDR
To manage chemically induced methemoglobinemia properly, a clinician must be aware of its pathophysiology, be skilled with the use of reducing agents such as methylene blue, and understand specific physiochemical properties of the toxin.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
A single intraperitoneal dose of EP was able to reduce methemoglobinemia induced by dapsone for a short period of time, but this effect was not sustained.
Severe Propanil [N-(3,4-Dichlorophenyl) Propanamide] Pesticide Self-Poisoning
TLDR
A retrospective case series of patients who were treated in the intensive care unit of and/or died in Anuradhapura General Hospital between 1998 and early 2002 indicates that propanil poisoning can be a severe form of self-poisoning, particularly in resource-poor settings.
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