Studies of the biochemical toxicology of uranyl nitrate in the rat

@article{Anthony1994StudiesOT,
  title={Studies of the biochemical toxicology of uranyl nitrate in the rat},
  author={Maria L. Anthony and Kevin P. R. Gartland and Christopher R. Beddell and John C. Lindon and Jeremy K. Nicholson},
  journal={Archives of Toxicology},
  year={1994},
  volume={68},
  pages={43-53}
}
High resolution 1H NMR spectroscopy of urine and plasma, conventional clinical chemical methods and histopathology have been applied to investigate the effects of uranyl nitrate (UN) on renal function and biochemistry in the Fischer 344 (F344) rat. Administration of UN (5–20 mg/kg) to male F344 rats resulted in a dose-related proximal nephropathy assessed conventionally by histopathology and urinary excretion of N-acetyl-ß-d-glucosaminidase (NAG), and related to changes in the patterns of low… CONTINUE READING

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