Studies of red cell stromal proteins in Tay-Sachs disease.

  title={Studies of red cell stromal proteins in Tay-Sachs disease.},
  author={John A. Balint and Emilios C. Kyriakides},
  journal={The Journal of clinical investigation},
  volume={47 8},
Hemoglobin-free red blood cell ghosts of nine patients with Tay-Sachs disease and 14 normal control subjects have been analyzed for content of total protein, hexosamines, individual amino acids, and sialic acid. Red cell ghosts from Tay-Sachs' children have been shown to contain significantly increased amounts of protein, hexosamine, threonine, and serine, and probably sialic acid, each of which was increased by approximately 25% over control values. These observations suggest that the red cell… CONTINUE READING