Studies of radon-exposed miner cohorts using a biologically based model: comparison of current Czech and French data with historic data from China and Colorado.

@article{Heidenreich2004StudiesOR,
  title={Studies of radon-exposed miner cohorts using a biologically based model: comparison of current Czech and French data with historic data from China and Colorado.},
  author={W. F. Heidenreich and Ladislav Tom{\'a}{\vs}ek and Agn{\`e}s Rogel and Dominique Laurier and Margot Tirmarche},
  journal={Radiation and environmental biophysics},
  year={2004},
  volume={43 4},
  pages={247-56}
}
The biologically based two-stage clonal expansion (TSCE) model is used to analyze lung cancer in several miners studies, two new ones (Czech, French) and two historic ones (Chinese, Colorado). In all cases, the model assumptions are identical. An action of radiation on initiation, promotion, and transformation is allowed. While all four studies indicate a highly significant action of radiation on promotion, the action on initiation is not significant in the French cohort, and barely significant… CONTINUE READING