Studies of methotrexate-induced limb dysplasias utilizing a 51chromium release assay.

Abstract

The folate antagonist methotrexate (MTX), widely used in chemotherapy, is a well-documented teratogen. However, the mechanism by which it exerts its effects is still unclear. Specifically, we have examined the cytotoxicity of MTX in vivo and in vitro and have looked at the relationship between cytotoxicity and teratogenesis. The chick embryo was utilized to… (More)

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Cite this paper

@article{Brewton1990StudiesOM, title={Studies of methotrexate-induced limb dysplasias utilizing a 51chromium release assay.}, author={R G Brewton and J A Maccabe}, journal={Teratology}, year={1990}, volume={41 2}, pages={211-21} }