Studies of in vitro red cell autoantibody production in normal donors and in patients with autoimmune hemolytic anemia.

The in vitro production of red cell autoantibodies (RBC AuAbs) has been investigated for better understanding of the pathogenesis of autoimmune hemolytic anemia (AIHA). Peripheral blood mononuclear cells (PBMNCs) were isolated and cultured for 14 days with or without added pokeweed mitogen (PWM), autologous RBCs, methyldopa, procainamide, and alpha… CONTINUE READING