Studies of human pancreatic elastase treatment of rabbit and human vein rings to predict human therapeutic doses

  title={Studies of human pancreatic elastase treatment of rabbit and human vein rings to predict human therapeutic doses},
  author={S. Burke and D. Bunton and Karen Bingham and E. Moss and Kimberly S. Bland and B. Starcher and Marco D. Wong and F. N. Franano},
  journal={Pharmacology Research & Perspectives},
  • S. Burke, D. Bunton, +5 authors F. N. Franano
  • Published 2016
  • Chemistry, Medicine
  • Pharmacology Research & Perspectives
  • Vascular tissue contains abundant elastic fibers that contribute to vessel elasticity. Vonapanitase (formerly PRT‐201) is a recombinant human chymotrypsin‐like elastase family member 1 (CELA1) shown to cleave the elastin component of elastic fibers, resulting in increased vessel diameter. The purpose of these current studies was to determine vein diameter, wall thickness, elastin content, and vonapanitase potency in veins used in a model of arteriovenous fistula (AVF) and in patients undergoing… CONTINUE READING
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