Studies of human cord blood dendritic cells: evidence for functional immaturity.

@article{Hunt1994StudiesOH,
  title={Studies of human cord blood dendritic cells: evidence for functional immaturity.},
  author={David W. C. Hunt and H. I. Huppertz and Hong Jiang and Ross E. Petty},
  journal={Blood},
  year={1994},
  volume={84 12},
  pages={
          4333-43
        }
}
We have isolated low-density, nonadherent, nonphagocytic, HLA-DR+ve cells with the morphology of dendritic cells (DCs) from the cord blood of full-term newborn infants. Relative to adult DCs, cord blood DCs were poor stimulators of the mixed leukocyte reaction when either adult or cord blood mononuclear cells (MNCs) or T lymphocytes were used as responder cells. In contrast, cord blood T cells and MNCs responded normally to allogeneic adult DCs. Cord blood DCs performed poorly as accessory… CONTINUE READING

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