Studies of human cord blood dendritic cells: evidence for functional immaturity.

  title={Studies of human cord blood dendritic cells: evidence for functional immaturity.},
  author={D. W. Hunt and H. Huppertz and H. Jiang and R. Petty},
  volume={84 12},
  • D. W. Hunt, H. Huppertz, +1 author R. Petty
  • Published 1994
  • Medicine
  • Blood
  • We have isolated low-density, nonadherent, nonphagocytic, HLA-DR+ve cells with the morphology of dendritic cells (DCs) from the cord blood of full-term newborn infants. Relative to adult DCs, cord blood DCs were poor stimulators of the mixed leukocyte reaction when either adult or cord blood mononuclear cells (MNCs) or T lymphocytes were used as responder cells. In contrast, cord blood T cells and MNCs responded normally to allogeneic adult DCs. Cord blood DCs performed poorly as accessory… CONTINUE READING
    194 Citations
    Neonatal dendritic cells.
    • 72
    Efficient priming of antigen-specific cytotoxic T lymphocytes by human cord blood dendritic cells.
    • 52
    • PDF
    Cord blood dendritic cells prevent the differentiation of naïve T-helper cells towards Th1 irrespective of their subtype
    • 27
    Developmental biology of the dendritic cell system
    • 14


    Human dendritic cells. Enrichment and characterization from peripheral blood
    • 348
    • PDF
    Deficient DR antigen expression on human cord blood monocytes: reversal with lymphokines.
    • 51
    Are cord blood B cells functionally mature?
    • 60
    Isolation and characterization of human peripheral blood dendritic cells.
    • 239