Studies of different female rat models of hypothalamic obesity.

Abstract

Hypothalamic obesity (HO) is a major and unsolved problem in patients with medial hypothalamic lesions and is associated with hyperinsulinemia and hyperleptinemia. The purpose of this study was to create a rodent model that mimics metabolic changes in HO for use in therapeutic testing. Female Sprague-Dawley rats were used to test the individual and combined… (More)

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Cite this paper

@article{Elfers2011StudiesOD, title={Studies of different female rat models of hypothalamic obesity.}, author={Clinton Thomas Elfers and Melissa M Ralston and Christian L Roth}, journal={Journal of pediatric endocrinology & metabolism : JPEM}, year={2011}, volume={24 3-4}, pages={131-7} }