Studies of a recombinant which inherited the haemagglutinin from the human influenza virus A/Hong Kong/1/68 (H3n2) and other genes from influenza virus A/duck/Ukraine/1/63 (H3N8).
@article{Ghendon1984StudiesOA,
title={Studies of a recombinant which inherited the haemagglutinin from the human influenza virus A/Hong Kong/1/68 (H3n2) and other genes from influenza virus A/duck/Ukraine/1/63 (H3N8).},
author={Yu. Ghendon and Alexander Klimov and V. P. Ginzburg},
journal={The Journal of general virology},
year={1984},
volume={65 ( Pt 1)},
pages={
165-72
}
}A recombinant (R3/3) has been obtained which inherited the gene coding for the haemagglutinin from human influenza virus A/Hong Kong/1/68 (H3N2), and seven other genes from influenza virus A/duck/Ukraine/1/63 (H3N8). The recombinant R3/3 had properties, a ts+ phenotype and a capability of reproducing in chick embryos, similar to those of the duck influenza virus, but, in contrast to this parent, had lost its ability to reproduce in organ cultures of colon of ducks and chickens as well as in…
5 Citations
Characterization of a 1980-swine recombinant influenza virus possessing H1 hemagglutinin and N2 neuraminidase similar to that of the earliest Hong Kong (H3N2) virus
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DNA-RNA hybridization could define the genomic composition of the recombinant, indicating that only the neuraminidase gene of this virus is derived from the earliest Hong Kong (H3N2)-like virus and remaining seven genes from swine (H1N1) virus.
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The analysis of the parental origin of the genes of 6 reassortants allowed to suggest that changes in the HA gene and in a polymerase gene were necessary for the acquisition of virulence by the A/USSR/90/77 virus in the course of adaptation to mice, whereas the changes in two other polymerase genes were not involved.
A novel highly pathogenic H5N8 avian influenza virus isolated from a wild duck in China
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