Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis

@article{Yam2009StudiesOA,
  title={Studies of a Ring-Cleaving Dioxygenase Illuminate the Role of Cholesterol Metabolism in the Pathogenesis of Mycobacterium tuberculosis},
  author={Katherine C. Yam and Igor D'Angelo and Rainer Kalscheuer and Haizhong Zhu and Jian-xin Wang and Victor Snieckus and Lan Ly and Paul J Converse and William Robert Jacobs and Natalie C. J. Strynadka and Lindsay D Eltis},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={517 - 549}
}
Mycobacterium tuberculosis, the etiological agent of TB, possesses a cholesterol catabolic pathway implicated in pathogenesis. This pathway includes an iron-dependent extradiol dioxygenase, HsaC, that cleaves catechols. Immuno-compromised mice infected with a DeltahsaC mutant of M. tuberculosis H37Rv survived 50% longer than mice infected with the wild-type strain. In guinea pigs, the mutant disseminated more slowly to the spleen, persisted less successfully in the lung, and caused little… CONTINUE READING
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