Studies of V beta 8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis.

@article{Stevens1992StudiesOV,
  title={Studies of V beta 8 T cell receptor peptide treatment in experimental autoimmune encephalomyelitis.},
  author={David B Stevens and William J. Karpus and Kenneth E Gould and Robert H. Swanborg},
  journal={Journal of neuroimmunology},
  year={1992},
  volume={37 1-2},
  pages={123-9}
}
Lewis rats immunized with T cell receptor (TCR) variable region peptide V beta 8 in complete Freund's adjuvant (CFA) were protected against experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein in CFA, although variable protection was also observed in rats injected with control peptide in CFA, or CFA alone. However, this adjuvant-mediated protection could be avoided by immunizing with TCR peptide in incomplete adjuvant (IFA). Clinical, but not histologic EAE was… CONTINUE READING