Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

@inproceedings{Muench2007StudiesOT,
  title={Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents},
  author={Stephen P Muench and Sean T Prigge and Rima McLeod and John B. Rafferty and Michael J. Kirisits and Craig W Roberts and Ernest Mui and David W. Rice},
  booktitle={Acta crystallographica. Section D, Biological crystallography},
  year={2007}
}
Recent studies have demonstrated that submicromolar concentrations of the biocide triclosan arrest the growth of the apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii and inhibit the activity of the apicomplexan enoyl acyl carrier protein reductase (ENR). The crystal structures of T. gondii and P. falciparum ENR in complex with NAD(+) and triclosan and of T. gondii ENR in an apo form have been solved to 2.6, 2.2 and 2.8 A, respectively. The structures of T. gondii ENR have… CONTINUE READING

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