Studies of Inhibitory Mechanisms of Propeptide-Like Cysteine Protease Inhibitors

@inproceedings{Nga2014StudiesOI,
  title={Studies of Inhibitory Mechanisms of Propeptide-Like Cysteine Protease Inhibitors},
  author={Bui Thi To Nga and Yuki Takeshita and Misa Yamamoto and Yoshimi Yamamoto},
  booktitle={Enzyme research},
  year={2014}
}
Mouse cytotoxic T-lymphocyte antigen-2α (CTLA-2α), Drosophila CTLA-2-like protein (crammer), and Bombyx cysteine protease inhibitor (BCPI) belong to a novel family of cysteine protease inhibitors (I29). Their inhibitory mechanisms were studied comparatively. CTLA-2α contains a cysteine residue (C75), which is essential for its inhibitory potency. The CTLA-2α monomer was converted to a disulfide-bonded dimer in vitro and in vivo. The dimer was fully inhibitory, but the monomer, which possessed a… CONTINUE READING