Studies of HLA, fertility and mate choice in a human isolate.

@article{Ober1999StudiesOH,
  title={Studies of HLA, fertility and mate choice in a human isolate.},
  author={Carole Ober},
  journal={Human reproduction update},
  year={1999},
  volume={5 2},
  pages={
          103-7
        }
}
  • C. Ober
  • Published 1 March 1999
  • Biology, Medicine
  • Human reproduction update
The role of human leukocyte antigen (HLA) genes in pregnancy and in human mate choice has been investigated in the Hutterites, an inbred population of European origins. High-resolution HLA haplotypes were defined by alleles at 16 loci in >1000 Hutterites. Prospective studies of pregnancy outcome previously demonstrated increased fetal loss rates among Hutterite couples matching for HLA-B antigens (P = 0.033) or for the entire 16-locus haplotype (P = 0.002). Among living children of couples… 

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References

SHOWING 1-10 OF 45 REFERENCES
HLA and mate choice.
  • T. Gill
  • Biology
    American journal of human genetics
  • 1998
TLDR
Results are consistent with the conclusion that Hutterite mate choice is influenced by HLA haplotypes, with an avoidance of spouses with haplotypes that are the same as one’s own.
HLA and mate choice in humans.
TLDR
The results of this study are consistent with the conclusion that Hutterite mate choice is influenced by HLA haplotypes, with an avoidance of spouses with haplotypes that are the same as one's own.
Human leukocyte antigen matching and fetal loss: results of a 10 year prospective study.
TLDR
Results are interpreted as evidence that matching for the entire 16-locus haplotype and/or alleles at an HLA-B-linked locus confers significant risk for fetal loss.
Ancestral and recombinant 16-locus HLA haplotypes in the Hutterites
TLDR
Hutterite MHC haplotype sequences are similar to those observed in outbred Caucasians, suggesting that the influence of HLA haplotypes on fetal loss and mating structure may be general.
Shared HLA antigens and reproductive performance among Hutterites.
TLDR
In the Hutterites, an inbred human isolate that proscribes contraception, the results demonstrate that sharing HLA antigens does not preclude normal pregnancy and caution should be exercised before concluding that shared HLAAntigens are solely responsible for repeated fetal losses.
Deficit of HLA homozygotes in a Caucasian isolate.
Adverse effects of human leukocyte antigen-DR sharing on fertility: a cohort study in a human isolate.
HLA: fertile territory for developmental genes?
TLDR
Current gene mapping of murine chromosome 17 and human chromosome 6 is discussed, in light of the spectrum of new genes that have been identified and the colinearity of genes in the two MHCs.
HLA: fertile territory for developmental genes?
  • D. Kostyu
  • Biology
    Critical reviews in immunology
  • 1994
TLDR
Current gene mapping of murine chromosome 17 and human chromosome 6 is discussed, in light of the spectrum of new genes that have been identified and the colinearity of genes in the two MHCs.
...
...