Studies in the viability of Mycobacterium leprae in human liver and bone marrow using thymectomized mouse foot pad technic.

Abstract

Since the introduction of the mouse foot pad technic for the cultivation of M. Zeprae all the results reported to date have been limited to experiments with bacilli obtained from skin biopsy. We have been investigating the viability of bacilli found in bone marrow and liver, especially since the temperature in these organs is known to be at least 2°F greater than the skin temperature. Further, we wanted to determine whether the bacilli in the bone marrow and liver represented only dead bacilli phagocytosed by macrophages or whether the bacilli in these organs were viable bacilli capable of multiplication and dissemination in the body.

Cite this paper

@article{Karat1972StudiesIT, title={Studies in the viability of Mycobacterium leprae in human liver and bone marrow using thymectomized mouse foot pad technic.}, author={A B Karat and Hazel E Harmer and Arumugam Saravana Kumar and Jennifer R. Albert}, journal={International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association}, year={1972}, volume={40 1}, pages={1-3} }