Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients.

@article{Bickers1977StudiesIP,
  title={Studies in porphyria. VI. Biosynthesis of porphyrins in mammalian skin and in the skin of porphyric patients.},
  author={David R. Bickers and L Keogh and Arleen B. Rifkind and L C Harber and A. Kappas},
  journal={The Journal of investigative dermatology},
  year={1977},
  volume={68 1},
  pages={5-9}
}
Porphyrin biosynthesis in mammalian skin and in skin obtained from patients with selected types of porphyria has been studied. Cutaneous porphyrinogenesis required the precursor delta-aminolevulinic acid (ALA) which, when added to murine, rat, and human skin in vitro, was rapidly converted to porphyrins. Total porphyrin content was quantitated by fluorescence assay, and spectral studies indicated that more than 80% of the porphyrin produced was protoporphyrin. The majority of skin… CONTINUE READING
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