Studies in Valine Biosynthesis

@inproceedings{Wixom2003StudiesIV,
  title={Studies in Valine Biosynthesis},
  author={Robert L. Wixom and JOHN H. WIKMAN and G. Boyd Howell},
  year={2003}
}
The steps in the pathway of formation of valine are: decarbosylation of pyruvate to an acetaldehyde-thiamine pyrophosphate intermediate which condenses with another molecule of pyruvate to yield ar-acetolactic acid, migration of the a-methyl carbon to form ar-keto-fl-hydroxyisovaleric acid, reduction of this acid to produce (Y ,&dihydroxyisovaleric acid, dehydration to yield ar-ketoisovaleric acid, and, finally, transamination to form valine. The reactions in the biogenesis of isoleucine are… CONTINUE READING

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