Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2.

@article{Munger1995StudiesET,
  title={Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2.},
  author={William Munger and Susan Quinn Dejoy and Robert Jeyaseelan and L W Torley and Kenneth H. Grabstein and J Eisenmann and Ray Paxton and Thomas Cox and Michael M. Wick and Suresh Shivarau Kerwar},
  journal={Cellular immunology},
  year={1995},
  volume={165 2},
  pages={289-93}
}
Interleukin-15 is a new cytokine that stimulates the proliferation of T cells and other cells of the immune system. Some of the biological properties of interleukin-15 overlap that of interleukin-2. Using murine models, the present studies have shown that interleukin-15, in vivo, is three to four times more potent than interleukin-2 in generating cytolytic effector splenocytes that lyse YAC target cells. It is approximately one-third as potent as interleukin-2 in inducing specific cytolytic… CONTINUE READING