Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.

@article{Frdrich2001StrychnogucinesAA,
  title={Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.},
  author={Michel Fr{\'e}d{\'e}rich and Marleen de Pauw and Carlos Hugo Prosperi and Monique Tits and Viviane Brandt and Jacques Penelle and Marie-Pierre Hayette and Patrick Demol and Luc Angenot},
  journal={Journal of natural products},
  year={2001},
  volume={64 1},
  pages={
          12-6
        }
}
A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI(50), 80 nM… 

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