Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.

  title={Strychnogucines A and B, two new antiplasmodial bisindole alkaloids from Strychnos icaja.},
  author={Michel Fr{\'e}d{\'e}rich and Marleen de Pauw and Carlos Hugo Prosperi and Monique Tits and Viviane Brandt and Jacques Penelle and Marie-Pierre Hayette and Patrick Demol and Luc Angenot},
  journal={Journal of natural products},
  volume={64 1},
A reinvestigation of Strychnos icaja roots has resulted in the isolation of two tertiary quasi-symmetric bisindole alkaloids named strychnogucines A (1) and B (2). Their structures were identified by means of spectroscopic data interpretation. Compound 2 was highly active in vitro and compound 1 moderately active against four strains of Plasmodium falciparum. Strychnogucine B (2) was more active against a chloroquine-resistant strain than against a chloroquine-sensitive one (best CI(50), 80 nM… 

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  • H. Moon
  • Chemistry, Medicine
    Phytotherapy research : PTR
  • 2010
The chloroform extracts of whole plants of Hypericum erectum were investigated for antiplasmodial activity against chloroquine‐sensitive strains of Plasmodium falciparum and five phloroglucinol derivatives, otogirin, showed notable growth inhibitory activity and showed no significant cytotoxicity evaluated using SK‐OV‐3 cancer cell line cells.


African Ethnobotany: Poisons and Drugs: Chemistry, Pharmacology, Toxicology
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Poisons and Drugs
Antibiotics are specific poisons that must selectively poison a molecular machine which is vital to the pathogenic organism, but which is not needed in the authors' bodies.