Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations.

@article{Svidritskiy2014StructuresOY,
  title={Structures of yeast 80S ribosome-tRNA complexes in the rotated and nonrotated conformations.},
  author={Egor Svidritskiy and Axel F. Brilot and Cha San Koh and Nikolaus Grigorieff and Andrei A Korostelev},
  journal={Structure},
  year={2014},
  volume={22 8},
  pages={1210-1218}
}
The structural understanding of eukaryotic translation lags behind that of translation on bacterial ribosomes. Here, we present two subnanometer resolution structures of S. cerevisiae 80S ribosome complexes formed with either one or two tRNAs and bound in response to an mRNA fragment containing the Kozak consensus sequence. The ribosomes adopt two globally different conformations that are related to each other by the rotation of the small subunit. Comparison with bacterial ribosome complexes… CONTINUE READING
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