Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre.

@article{Boucher2005StructuresOT,
  title={Structures of two superoxide dismutases from Bacillus anthracis reveal a novel active centre.},
  author={Ian W Boucher and Anne K Kalliomaa and Vladimir M. Levdikov and Elena V. Blagova and Mark J. Fogg and James A Brannigan and Keith S Wilson and Anthony James Wilkinson},
  journal={Acta crystallographica. Section F, Structural biology and crystallization communications},
  year={2005},
  volume={61 Pt 7},
  pages={621-4}
}
The BA4499 and BA5696 genes of Bacillus anthracis encode proteins homologous to manganese superoxide dismutase, suggesting that this organism has an expanded repertoire of antioxidant proteins. Differences in metal specificity and quaternary structure between the dismutases of prokaryotes and higher eukaryotes may be exploited in the development of therapeutic antibacterial compounds. Here, the crystal structure of two Mn superoxide dismutases from B. anthracis solved to high resolution are… CONTINUE READING

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