Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.

@article{Xue2008StructuresOT,
  title={Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design.},
  author={Xiaoyu Xue and Hongwei Yu and Haitao Yang and F. Xue and Zhixin Wu and Wei Shen and Jun Li and Zhe Zhou and Yi Ding and Qi Zhao and Xuejun Cai Zhang and Ming Xing Liao and Mark Bartlam and Zihe Rao},
  journal={Journal of virology},
  year={2008},
  volume={82 5},
  pages={2515-27}
}
Coronaviruses (CoVs) can infect humans and multiple species of animals, causing a wide spectrum of diseases. The coronavirus main protease (M(pro)), which plays a pivotal role in viral gene expression and replication through the proteolytic processing of replicase polyproteins, is an attractive target for anti-CoV drug design. In this study, the crystal… CONTINUE READING