Structures of the tRNA export factor in the nuclear and cytosolic states

  title={Structures of the tRNA export factor in the nuclear and cytosolic states},
  author={Atlanta G Cook and Noemi Fukuhara and Martin Jinek and Elena Conti},
Transfer RNAs are among the most ubiquitous molecules in cells, central to decoding information from messenger RNAs on translating ribosomes. In eukaryotic cells, tRNAs are actively transported from their site of synthesis in the nucleus to their site of function in the cytosol. This is mediated by a dedicated nucleo-cytoplasmic transport factor of the karyopherin-β family (Xpot, also known as Los1 in Saccharomyces cerevisiae). Here we report the 3.2 Å resolution structure of… CONTINUE READING
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