Structures of the spectrin-ankyrin interaction binding domains.

  title={Structures of the spectrin-ankyrin interaction binding domains.},
  author={Jonathan J Ipsaro and Lei Huang and Alfonso Mondrag{\'o}n},
  volume={113 22},
As key components of the erythrocyte membrane skeleton, spectrin and ankyrin specifically interact to tether the spectrin cytoskeleton to the cell membrane. The structure of the spectrin binding domain of ankyrin and the ankyrin binding domain of spectrin have been solved to elucidate the structural basis for ankyrin-spectrin recognition. The structure of repeats 14 and 15 of spectrin shows that these repeats are similar to all other spectrin repeats. One feature that could account for the… CONTINUE READING


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