Structures of the human ceramide activator protein saposin D.

@article{Popovic2008StructuresOT,
  title={Structures of the human ceramide activator protein saposin D.},
  author={Konstantin Popovic and Gilbert G Priv{\'e}},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2008},
  volume={64 Pt 5},
  pages={
          589-94
        }
}
Saposin D is a sphingolipid activator protein required for the lysosomal breakdown of ceramide to a fatty acid and sphingosine by acid ceramidase. The crystal structure of saposin D has been determined in two different crystal forms, resulting in a total of six crystallographically independent views of this small 80-amino-acid protein. All of the structures are highly similar and reveal the monomeric form of the saposin fold previously seen in the crystal structures of saposins A and C. Saposin… CONTINUE READING
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