Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.

@article{Dunkle2011StructuresOT,
  title={Structures of the bacterial ribosome in classical and hybrid states of tRNA binding.},
  author={Jack A. Dunkle and Leyi Wang and Michael B. Feldman and Arto Pulk and Vincent B. Chen and Gary J. Kapral and Jonas Noeske and Jane S. Richardson and Scott C. Blanchard and Jamie H D Cate},
  journal={Science},
  year={2011},
  volume={332 6032},
  pages={981-4}
}
During protein synthesis, the ribosome controls the movement of tRNA and mRNA by means of large-scale structural rearrangements. We describe structures of the intact bacterial ribosome from Escherichia coli that reveal how the ribosome binds tRNA in two functionally distinct states, determined to a resolution of ~3.2 angstroms by means of x-ray crystallography. One state positions tRNA in the peptidyl-tRNA binding site. The second, a fully rotated state, is stabilized by ribosome recycling… CONTINUE READING
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