Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.

@article{Kryger2000StructuresOR,
  title={Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II.},
  author={G Kryger and Michal Harel and Kurt Giles and Lilly Toker and Baruch Velan and Arie Lazar and Chanoch Kronman and Dov Barak and Naomi Ariel and Avigdor Shafferman and Israel Silman and Joel L. Sussman},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2000},
  volume={56 Pt 11},
  pages={1385-94}
}
Structures of recombinant wild-type human acetylcholinesterase and of its E202Q mutant as complexes with fasciculin-II, a 'three-finger' polypeptide toxin purified from the venom of the eastern green mamba (Dendroaspis angusticeps), are reported. The structure of the complex of the wild-type enzyme was solved to 2.8 A resolution by molecular replacement starting from the structure of the complex of Torpedo californica acetylcholinesterase with fasciculin-II and verified by starting from a… CONTINUE READING
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