Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor.

@article{Giannese2013StructuresOP,
  title={Structures of purine nucleosidase from Trypanosoma brucei bound to isozyme-specific trypanocidals and a novel metalorganic inhibitor.},
  author={F. Giannese and M. Berg and P. Van der Veken and V. Castagna and P. Tornaghi and K. Augustyns and M. Degano},
  journal={Acta crystallographica. Section D, Biological crystallography},
  year={2013},
  volume={69 Pt 8},
  pages={
          1553-66
        }
}
Sleeping sickness is a deadly disease that primarily affects sub-Saharan Africa and is caused by protozoan parasites of the Trypanosoma genus. Trypanosomes are purine auxotrophs and their uptake pathway has long been appreciated as an attractive target for drug design. Recently, one tight-binding competitive inhibitor of the trypanosomal purine-specific nucleoside hydrolase (IAGNH) showed remarkable trypanocidal activity in a murine model of infection. Here, the enzymatic characterization of T… Expand
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