Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode.

@article{Lu2014StructuresOK,
  title={Structures of kibdelomycin bound to Staphylococcus aureus GyrB and ParE showed a novel U-shaped binding mode.},
  author={Jun Hui Lu and Sangita Patel and Nandini Sharma and Stephen M. Soisson and Ryuta Kishii and Masaya Takei and Yasumichi Fukuda and Kevin J Lumb and Sheo Baran Singh},
  journal={ACS chemical biology},
  year={2014},
  volume={9 9},
  pages={
          2023-31
        }
}
Bacterial resistance to antibiotics continues to pose serious challenges as the discovery rate for new antibiotics fades. Kibdelomycin is one of the rare, novel, natural product antibiotics discovered recently that inhibits the bacterial DNA synthesis enzymes gyrase and topoisomerase IV. It is a broad-spectrum, Gram-positive antibiotic without cross-resistance to known gyrase inhibitors, including clinically effective quinolones. To understand its mechanism of action, binding mode, and lack of… CONTINUE READING

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