Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.

@article{Burke2012StructuresOI,
  title={Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.},
  author={Jason R Burke and Greg L. Hura and Seth M Rubin},
  journal={Genes & development},
  year={2012},
  volume={26 11},
  pages={1156-66}
}
Cyclin-dependent kinase (Cdk) phosphorylation of the Retinoblastoma protein (Rb) drives cell proliferation through inhibition of Rb complexes with E2F transcription factors and other regulatory proteins. We present the first structures of phosphorylated Rb that reveal the mechanism of its inactivation. S608 phosphorylation orders a flexible "pocket" domain loop such that it mimics and directly blocks E2F transactivation domain (E2F(TD)) binding. T373 phosphorylation induces a global… CONTINUE READING