Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit.

Abstract

Structures of anisomycin, chloramphenicol, sparsomycin, blasticidin S, and virginiamycin M bound to the large ribosomal subunit of Haloarcula marismortui have been determined at 3.0A resolution. Most of these antibiotics bind to sites that overlap those of either peptidyl-tRNA or aminoacyl-tRNA, consistent with their functioning as competitive inhibitors of… (More)

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@article{Hansen2003StructuresOF, title={Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit.}, author={Jeffrey L. Hansen and Peter B Moore and Thomas A Steitz}, journal={Journal of molecular biology}, year={2003}, volume={330 5}, pages={1061-75} }