Structures of eleven zervamicin and two emerimicin peptide antibiotics studied by fast atom bombardment mass spectrometry

  title={Structures of eleven zervamicin and two emerimicin peptide antibiotics studied by fast atom bombardment mass spectrometry},
  author={K. Rinehart and L. A. Gaudioso and M. Moore and R. C. Pandey and J. C. Cook and M. Barber and R. Sedgwick and R. Bordoli and A. Tyler and B. Green},
  journal={Journal of the American Chemical Society},
In situ mass spectrometry monitoring of fungal cultures led to the identification of four peptaibols with a rare threonine residue.
A mass spectrometry surface sampling technique was applied to screen the chemistry of fungal cultures in situ and four previously undescribed peptaibols, all containing a rare threonine residue, were identified from a fungal culture. Expand
Droplet probe: coupling chromatography to the in situ evaluation of the chemistry of nature.
This review discusses the one in situ analysis technique that incorporates chromatography, being the droplet-liquid microjunction-surface sampling probe, which is more easily termed "droplet probe", and provides perspective on why scientists, particularly those steeped in natural products chemistry training, may want to include chromatography in in situ analyses. Expand
The influence of solvent on conformational properties of peptides with Aib residue—a DFT study
The results of the calculations show that both derivatives with the Aib residue in the gas phase prefer structures stabilized by intramolecular N–H⋯O hydrogen bonds, i.e., C5 and C7 conformations, while polar solvent promotes helical conformation with φ, ψ values equal to -/−60°, +/−40°. Expand
Biosynthesis and Molecular Genetics of Peptaibiotics—Fungal Peptides Containing Alpha, Alpha-Dialkyl Amino Acids
Peptaibiotics are peptide secondary metabolites rich in alpha, alpha-dialkyl amino acids from filamentous fungi, especially the members of the genus Trichoderma (anamorph of Hypocrea). In contrast toExpand
Insights into the mechanisms of action of host defence peptides from biophysical and structural investigations
1 Bechinger B. Insights into themechanisms of action of host defence peptides from biophysical and structural investigations. J. Pept. Sci. 2011; 17: 306–314. DOI: 10.1002/psc.1343. 2 Rinehart KL,Expand
Peptaibiotics and peptaibols from fungi
Time-of-flight mass spectrometry (TOFMS): From niche to mainstream
Abstract World War II electronic advances suggested the use of time-of-flight for mass measurements, leading to the development of a commercial TOFMS instrument by Bendix. This instrument usedExpand
Peptaibol Antiamoebin I: Spatial Structure, Backbone Dynamics, Interaction with Bicelles and Lipid‐Protein Nanodiscs, and Pore Formation in Context of Barrel‐Stave Model
The observed extensive intramolecular dynamics explains the relatively low activity of Aam‐I and similarly to the mechanism proposed for Zrv‐IIB and other peptaibols. Expand
The N-terminal nonapeptide of cephaibols A and C: a naturally occurring example of mismatched helical screw-sense control.
It is shown by NMR and CD spectroscopy that the peptide containing the chiral amino acids Phe and Leu in the naturally occurring relative configuration exists in solution as an interconverting mixture of helical screw-sense conformers. Expand