Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.

@article{Kim2013StructuresOC,
  title={Structures of complexes comprised of Fischerella transcription factor HetR with Anabaena DNA targets.},
  author={Youngchang Kim and Zi Ye and Grazyna Joachimiak and Patrick Videau and Jasmine Young and Kathryn Hurd and Sean M. Callahan and Piotr Gornicki and Jindong Zhao and Robert Haselkorn and Andrzej Joachimiak},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 19},
  pages={E1716-23}
}
HetR is an essential regulator of heterocyst development in cyanobacteria. Many mutations in HetR render Anabaena incapable of nitrogen fixation. The protein binds to a DNA palindrome upstream of hetP and other genes. We have determined the crystal structures of HetR complexed with palindromic DNA targets, 21, 23, and 29 bp at 2.50-, 3.00-, and 3.25-Å resolution, respectively. The highest-resolution structure shows fine details of specific protein-DNA interactions. The lower-resolution… CONTINUE READING
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