Structures of bacterial homologues of SWEET transporters in two distinct conformations

  title={Structures of bacterial homologues of SWEET transporters in two distinct conformations},
  author={Yan Xu and Yuyong Tao and L. S. Cheung and Chao Fan and Li-Qing Chen and Sophia Xu and Kay Perry and Wolf Bernd Frommer and Liang Feng},
SWEETs and their prokaryotic homologues are monosaccharide and disaccharide transporters that are present from Archaea to plants and humans. SWEETs play crucial roles in cellular sugar efflux processes: that is, in phloem loading, pollen nutrition and nectar secretion. Their bacterial homologues, which are called SemiSWEETs, are among the smallest known transporters. Here we show that SemiSWEET molecules, which consist of a triple-helix bundle, form symmetrical, parallel dimers, thereby… CONTINUE READING
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