Structures of aromatic inhibitors of influenza virus neuraminidase.

  title={Structures of aromatic inhibitors of influenza virus neuraminidase.},
  author={Mark J Jedrzejas and Shashi Bhushan Singh and Wayne J. Brouillette and William Graeme Laver and Gillian M. Air and Ming Luo},
  volume={34 10},
Neuraminidase (NA), a surface glycoprotein of influenza virus, is a potential target for design of antiinfluenza agents. The crystal structure of influenza virus neuraminidase showed that in the active site 11 residues are universally conserved among all strains known so far. Several potent inhibitors based on the carbohydrate compound 2-deoxy-2,3-didehydro-D-N-acetylneuraminic acid (DANA) have been shown to bind to the conserved active site and to reduce virus infection in animals when… CONTINUE READING


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