Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding

@inproceedings{Ioannes2011StructuresOA,
  title={Structures of apo IRF-3 and IRF-7 DNA binding domains: effect of loop L1 on DNA binding},
  author={Pablo de Ioannes and Carlos Escalante and Aneel K. Aggarwal},
  booktitle={Nucleic acids research},
  year={2011}
}
Interferon regulatory factors IRF-3 and IRF-7 are transcription factors essential in the activation of interferon-β (IFN-β) gene in response to viral infections. Although, both proteins recognize the same consensus IRF binding site AANNGAAA, they have distinct DNA binding preferences for sites in vivo. The X-ray structures of IRF-3 and IRF-7 DNA binding domains (DBDs) bound to IFN-β promoter elements revealed flexibility in the loops (L1-L3) and the residues that make contacts with the target… CONTINUE READING

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