• Biology, Medicine
  • Published in
    Nature Structural &Molecular…
    2010
  • DOI:10.1038/nsmb.1795

Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium

@article{Wernimont2010StructuresOA,
  title={Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium},
  author={Amy K. Wernimont and Jennifer D. Artz and Patrick J. Finerty and Yu-hui Lin and Mehrnaz Amani and Abdellah Allali-Hassani and Guillermo A. Senisterra and Masoud Vedadi and Wolfram Tempel and Farrell Mackenzie and Irene Chau and Sebastian Lourido and L. David Sibley and Raymond Hui},
  journal={Nature Structural &Molecular Biology},
  year={2010},
  volume={17},
  pages={596-601}
}
Calcium-dependent protein kinases (CDPKs) have pivotal roles in the calcium-signaling pathway in plants, ciliates and apicomplexan parasites and comprise a calmodulin-dependent kinase (CaMK)-like kinase domain regulated by a calcium-binding domain in the C terminus. To understand this intramolecular mechanism of activation, we solved the structures of the autoinhibited (apo) and activated (calcium-bound) conformations of CDPKs from the apicomplexan parasites Toxoplasma gondii and… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 80 CITATIONS, ESTIMATED 48% COVERAGE

New Opportunities in the Structure-based Design of Anti-Protozoan Agents.

VIEW 4 EXCERPTS
HIGHLY INFLUENCED

Allosteric activation of apicomplexan calcium-dependent protein kinases.

VIEW 9 EXCERPTS
CITES BACKGROUND & METHODS

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.

VIEW 14 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Structural and evolutionary divergence of eukaryotic protein kinases in Apicomplexa

VIEW 24 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2010
2019

CITATION STATISTICS

  • 14 Highly Influenced Citations

  • Averaged 8 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 31 REFERENCES

A unique variation of the ATP binding site makes Toxoplasma gondii calcium-dependent protein kinase 1 a drug target for selective kinase inhibitors

  • Ojo, K.K
  • Nat. Struct. Mol. Biol. advance online publication,
  • 2010

phosphorylation by a calcium-dependent protein kinase

  • Green, J. L. et al. The motor complex of Plasmodium falciparum
  • J. Biol. Chem. 283, 30980–30989
  • 2008