Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.

@article{Wu2011StructuresOA,
  title={Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies.},
  author={Meiting Wu and Young-jun Park and Els Pardon and Stewart Turley and Andrew Hayhurst and Junpeng Deng and Jan Steyaert and Wim G. J. Hol},
  journal={Journal of structural biology},
  year={2011},
  volume={174 1},
  pages={124-36}
}
Several major global diseases are caused by single-cell parasites called trypanosomatids. These organisms exhibit many unusual features including a unique and essential U-insertion/deletion RNA editing process in their single mitochondrion. Many key RNA editing steps occur in ∼20S editosomes, which have a core of 12 proteins. Among these, the "interaction protein" KREPA6 performs a central role in maintaining the integrity of the editosome core and also binds to ssRNA. The use of llama single… CONTINUE READING