Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding

  title={Structures of Two Melanoma-Associated Antigens Suggest Allosteric Regulation of Effector Binding},
  author={Joseph A. Newman and Christopher D. O. Cooper and Anette K. Roos and Hazel Aitkenhead and Udo C. T. Oppermann and Hearn Jay Cho and R. Ben Osman and Opher Gileadi and Hiroshi Shiku},
  booktitle={PloS one},
The MAGE (melanoma associated antigen) protein family are tumour-associated proteins normally present only in reproductive tissues such as germ cells of the testis. The human genome encodes over 60 MAGE genes of which one class (containing MAGE-A3 and MAGE-A4) are exclusively expressed in tumours, making them an attractive target for the development of targeted and immunotherapeutic cancer treatments. Some MAGE proteins are thought to play an active role in driving cancer, modulating the… CONTINUE READING
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