Structures of Ras superfamily effector complexes: What have we learnt in two decades?

@article{Mott2015StructuresOR,
  title={Structures of Ras superfamily effector complexes: What have we learnt in two decades?},
  author={Helen R Mott and Darerca Owen},
  journal={Critical reviews in biochemistry and molecular biology},
  year={2015},
  volume={50 2},
  pages={85-133}
}
The Ras superfamily small G proteins are master regulators of a diverse range of cellular processes and act via downstream effector molecules. The first structure of a small G protein-effector complex, that of Rap1A with c-Raf1, was published 20 years ago. Since then, the structures of more than 60 small G proteins in complex with their effectors have been published. These effectors utilize a diverse array of structural motifs to interact with the G protein fold, which we have divided into four… CONTINUE READING
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