Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection

@inproceedings{Neu2012StructuresOM,
  title={Structures of Merkel Cell Polyomavirus VP1 Complexes Define a Sialic Acid Binding Site Required for Infection},
  author={Ursula Neu and H Hengel and B{\"a}rbel Sabine Blaum and Rachel M. Schowalter and Dennis G. Macejak and Michel Gilbert and Warren W. Wakarchuk and Akihiro Imamura and Hiromune Ando and Makoto Kiso and Niklas Arnberg and Robert L. Garcea and Thomas Peters and Christopher B Buck and Thilo Stehle},
  booktitle={PLoS pathogens},
  year={2012}
}
The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals. Conflicting reports suggest that cellular glycans containing sialic acid (Neu5Ac) may play a role in MCPyV infectious entry. To address this question, we solved X-ray structures of the MCPyV major capsid protein VP1 both alone and in complex with several sialylated oligosaccharides. A shallow binding site on the apical surface of… CONTINUE READING

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