Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

@article{Orans2011StructuresOH,
  title={Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family},
  author={Jillian Orans and Elizabeth A. McSweeney and Ravi R. Iyer and Michael A. Hast and Homme W. Hellinga and Paul L. Modrich and Lorena S. Beese},
  journal={Cell},
  year={2011},
  volume={145},
  pages={212-223}
}
Human exonuclease 1 (hExo1) plays important roles in DNA repair and recombination processes that maintain genomic integrity. It is a member of the 5' structure-specific nuclease family of exonucleases and endonucleases that includes FEN-1, XPG, and GEN1. We present structures of hExo1 in complex with a DNA substrate, followed by mutagenesis studies, and propose a common mechanism by which this nuclease family recognizes and processes diverse DNA structures. hExo1 induces a sharp bend in the DNA… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 71 references

Human exonuclease I is required for 5' and 3' mismatch repair.

The Journal of biological chemistry • 2002
View 11 Excerpts
Highly Influenced

Interactions of mutant and wild-type flap endonucleases with oligonucleotide substrates suggest an alternative model of DNA binding.

Proceedings of the National Academy of Sciences of the United States of America • 2002
View 5 Excerpts
Highly Influenced

Crystallography & NMR system: A new software suite for macromolecular structure determination.

Acta crystallographica. Section D, Biological crystallography • 1998
View 5 Excerpts
Highly Influenced

Denzo and Scalepack programs: An oscillation data processing suite for macromolecular crystallography

Z. Otwinowski
1998
View 2 Excerpts
Highly Influenced

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