Structures of HO(2)-Co(III)bleomycin A(2) bound to d(GAGCTC)(2) and d(GGAAGCTTCC)(2): structure-reactivity relationships of Co and Fe bleomycins.

@article{Zhao2002StructuresOH,
  title={Structures of HO(2)-Co(III)bleomycin A(2) bound to d(GAGCTC)(2) and d(GGAAGCTTCC)(2): structure-reactivity relationships of Co and Fe bleomycins.},
  author={Chunqing Zhao and Chuanwu Xia and Qunkai Mao and Holger F. F{\"o}rsterling and Eugene F. DeRose and William E. Antholine and Witold K Subczynski and David H. Petering},
  journal={Journal of inorganic biochemistry},
  year={2002},
  volume={91 1},
  pages={259-68}
}
HO(2)-Co(III)bleomycin is a model for HO(2)-Fe(III)bleomycin, which initiates single and double strand cleavage of DNA. In order to enlarge the understanding of its structure and reactivity, three-dimensional structures of HO(2)-Co(III)bleomycin bound to two DNA oligomers, d(GAGCTC)(2) (I) and d(GGAAGCTTCC)(2) (II), that have 5'-GC-3' binding sites, have been determined by nuclear magnetic resonance (NMR) methods. Besides previously recognized determinants of binding selectivity, a probable… CONTINUE READING

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