Structures of Anabaena calcium-binding protein CcbP: insights into Ca2+ signaling during heterocyst differentiation.

@article{Hu2011StructuresOA,
  title={Structures of Anabaena calcium-binding protein CcbP: insights into Ca2+ signaling during heterocyst differentiation.},
  author={Yunfei Hu and Xinxin Zhang and Yunming Shi and Yanfeng Zhou and Wei Zhang and Xiao-dong Su and Bin Xia and Jindong Zhao and Changwen Jin},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 14},
  pages={12381-8}
}
Ca2+-binding proteins play pivotal roles in both eukaryotic and prokaryotic cells. CcbP from cyanobacterium Anabaena sp. strain PCC 7120 is a major Ca2+-binding protein involved in heterocyst differentiation, a process that forms specialized nitrogen-fixing cells. The three-dimensional structures of both Ca2+-free and Ca2+-bound forms of CcbP are essential for elucidating the Ca2+-signaling mechanism. However, CcbP shares low sequence identity with proteins of known structures, and its Ca2… CONTINUE READING