Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein.

@article{Deng2006StructuresAP,
  title={Structures and polymorphic interactions of two heptad-repeat regions of the SARS virus S2 protein.},
  author={Yiqun Deng and Jie Liu and Qi Zheng and Wei Yong and Min Lu},
  journal={Structure},
  year={2006},
  volume={14 5},
  pages={889-99}
}
Entry of SARS coronavirus into its target cell requires large-scale structural transitions in the viral spike (S) glycoprotein in order to induce fusion of the virus and cell membranes. Here we describe the identification and crystal structures of four distinct alpha-helical domains derived from the highly conserved heptad-repeat (HR) regions of the S2 fusion subunit. The four domains are an antiparallel four-stranded coiled coil, a parallel trimeric coiled coil, a four-helix bundle, and a six… CONTINUE READING

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